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应用酶联免疫测定法检测2型糖尿病并发糖尿病肾病22例、并发视网膜病变20例、并发神经病变18例、无并发症20例及正常对照20例的空腹血浆抵抗素水平。结果:2型糖尿病有微血管病变组和无并发症组与正常对照组相比,血浆抵抗素水平差异均有显著性意义(P<0.01);应用胰岛素治疗后与治疗前相比,血浆抵抗素水平差异有显著性意义(P<0.01)。结果提示抵抗素在2型糖尿病的发病机制中可能起某种作用;应用胰岛素治疗后,抵抗素水平降低,表明胰岛素抑制抵抗素表达。
Enzyme-linked immunosorbent assay was used to detect fasting plasma resistin in 22 patients with type 2 diabetes mellitus complicated with diabetic nephropathy, 20 with retinopathy, 18 with neuropathy, 20 without complications and 20 normal controls. Results: Compared with the normal control group, there was significant difference in plasma resistin levels between type 2 diabetes mellitus group and non-complication group (P <0.01). Compared with before treatment, plasma resistin The level of difference was significant (P <0.01). The results suggest that resistin may play a role in the pathogenesis of type 2 diabetes. After insulin therapy, the level of resistin is reduced, indicating that insulin inhibits the expression of resistin.