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方法:1976年10月～1980年4月对45例急性淋巴细胞白血病患儿进行研究,患儿全部都在维持化疗期间出现骨髓复发,以后再次获得缓解。年龄1～17岁。在获得第二次缓解后采用维持治疗并进行随访。其中21例(化疗组)因无合适供体而采用一般的联合化疗,多数患者第1天静注氨甲喋呤(MTX),开始剂量100mg/M~2,以后按50mg/M~2递增,直至毒性剂量。用上药24 h 后加肌注 L-门冬酰氨酶1,500IU/M~2,某些患者加静注长春新碱(VCR)1.5mg/M~2。24例(移植组)在第二次缓解后即交替用大剂量环磷酰氨(CTX)、全身照射和骨髓移植。植前准备:植前8、4天鞘内 MTX12mg/M~2,植前5、4天 CTX60mg/kg,当天全身~(60钴照射920～1,000rad。23例的骨髓是 HLA 相容的同胞,1例的
Methods: From October 1976 to April 1980, 45 children with acute lymphoblastic leukemia were studied. All of the children had bone marrow recurrence during the maintenance chemotherapy and were relieved again later. Age 1 to 17 years old. Maintenance therapy was followed up after the second remission. Twenty-one of the 21 patients (chemotherapy group) received general chemotherapy in combination with no suitable donor. Most patients received methotrexate (MTX) intravenously on day 1 with a starting dose of 100 mg / m 2 and then 50 mg / m 2 until toxicity dose. After 24 h, the mice were intramuscularly injected with 1,500 IU / M ~ 2 L-asparaginase, and some patients were given intravenous vincristine (VCR) 1.5 mg / M ~ 2.24 (transplantation group) After the second remission that is alternating with high dose of cyclophosphamide (CTX), systemic irradiation and bone marrow transplantation. Preplant preparation: 8,4 days before transplantation intrathecal MTX12mg / M ~ 2, CTX60mg / kg 5,4 days before transplantation, the whole body the day ~ (60 cobalt irradiation 920 ~ 1,000rad.23 cases of bone marrow is HLA compatible siblings , 1 case of