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作者研究了在凝血酶原和因子Ⅹ的混合物中,1～30％浓度的聚乙二醇4000能加速凝血酶生成。在5mM CaCl_2存在的情况下,聚乙二醇4000在1％以上的浓度时都能引起凝血酶原激活。在14～20％浓度的聚乙二醇4000时,可见凝血酶原的激活高峰。聚乙二醇的作用明显依赖于其分子量:分子量大于2000的聚乙二醇适合加速凝血酶生成。在最佳条件下,在CaCl_2存在时,聚乙二醇4000促进所有的凝血酶原转变为凝血酶及其衍生物。
The authors studied that in a mixture of prothrombin and factor X, 1 to 30% concentration of polyethylene glycol 4000 accelerates thrombin generation. In the presence of 5 mM CaCl 2, polyethylene glycol 4000 can cause prothrombin activation at concentrations above 1%. In the 14 ~ 20% concentration of polyethylene glycol 4000, we can see the peak of prothrombin activation. The effect of polyethylene glycol depends significantly on its molecular weight: polyethylene glycol with a molecular weight greater than 2000 is suitable for accelerating thrombin generation. Under optimal conditions, polyethylene glycol 4000 promotes the conversion of all prothrombin to thrombin and its derivatives in the presence of CaCl 2.