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目的分析喹诺酮类药物在临床使用过程中的不良反应发生情况,为提高其临床用药的合理性提供参考依据。方法选择本院2012年1月至2012年12月接收,使用喹诺酮类药物治疗,在用药过程中出现不良反应的179例患者为研究对象,对其临床资料及不良反应报告进行回顾性分析。结果 179例药物不良反应共涉及8种喹诺酮类药物,累及消化、呼吸、循环、中枢等多个系统,以皮肤过敏、消化道反应、及中枢神经系统毒性等为主要表现形式。结论喹诺酮类药物临床不良反应发生率较高,在临床用药时,应加强监管,密切防范,除严格按说明书要求进行应用及配伍外,尚需考虑患者过敏体质、身体素质等个体化情况,做到合理用药,尽量减少不良反应的发生,以保证患者的健康和安全。
Objective To analyze the occurrence of adverse reactions of quinolones in clinical use and to provide a reference for improving the rationality of their clinical use. Methods A total of 179 patients who received quinolone therapy during January 2012 to December 2012 in our hospital were included in the study. The clinical data and adverse reaction reports were retrospectively analyzed. Results 179 cases of adverse drug reactions involving a total of eight quinolones, involving digestive, respiratory, circulatory, central and other systems, with skin allergies, gastrointestinal reactions, and the central nervous system toxicity as the main manifestations. Conclusions Quinolones have a high incidence of clinical adverse reactions. They should be supervised and closely monitored in clinical use. In addition to the application and compatibility of the quinolones in accordance with the instructions, individualized allergic constitution and physical fitness need to be considered To rational use of drugs, minimize the incidence of adverse reactions to ensure the patient’s health and safety.