海克替啶分解产物的合成和结构阐明

来源 :国外医学.药学分册 | 被引量 : 0次 | 上传用户:lihongde313
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海克替啶是一种六氢嘧啶衍生物,由于有好的抑菌和杀真菌作用而用作漱口溶液或消毒剂。它是一种油状液体,有弱的似胺的气味,易溶于有机溶剂氯仿、丙酮、乙醇、甲醇、苯和正己烷,但几乎不溶于水。海克替啶虽然在有机溶液中很稳定,但在水溶液中,特别是通过弱酸的催化,会发生快速的 Hexetidine is a hexamidine derivative used as a mouthwash solution or disinfectant due to its good bacteriostatic and fungicidal effects. It is an oily liquid with a weak, amine-like odor and is readily soluble in organic solvents such as chloroform, acetone, ethanol, methanol, benzene and n-hexane but is practically insoluble in water. Hexetidine, although stable in organic solutions, can occur rapidly in aqueous solutions, especially catalyzed by weak acids
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