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长效醋酸甲孕酮(DMPA)已被广泛用作长效避孕药。随着 DMPA 避孕效果首次报告后(1966年),就建立了避孕药现代投药的标准方法,即每次150rag每3个月1次。关于 DMPA 使用不同剂量对抑制排卵的效能方面的资料报导不多。最近Fotherby 等报告了泰国妇女对 DMPA 不同剂量的药代动力学研究,结果表明,DMPA 剂量低于160mg 仍保持不排卵的效能。由积累的资料表明几种避孕药和一些合成类固醇避孕药的代谢和药代动力学在不同种族的人群中可能有差别。
Long-acting medroxyprogesterone acetate (DMPA) has been widely used as a long-acting contraceptive. With the first report of the DMPA contraceptive effect (1966), a standard method of modern contraceptive use has been established, ie every 150rag every three months. Little information has been reported on the efficacy of different dosages of DMPA in inhibiting ovulation. Recently, Fotherby et al. Reported Thai women’s pharmacokinetic studies on different doses of DMPA. The results showed that DMPA maintained ovulation potency below 160 mg. The accumulated data suggest that the metabolism and pharmacokinetics of several contraceptives and some synthetic steroid contraceptives may differ among people of different ethnic groups.