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Objective: To evaluate the effect of Qingreliangxue method compared with Acitretin Capsules on clinical efficacy of psoriasis and serum inflammatory cytokines. Methods:The computer searches databases such as CNKI, Wanfang, VIP, PubMed, Embase and Cochrane Library. The search time is from the time the library is built until December 2019. According to the criteria for screening and selection of studies, extract data, use risk assessment tools for quality evaluation, and use Revman 5.3 software to perform meta-analysis on the outcome indicators of the included studis. Results: Finally, 20 studies were included, with a total of 1592 patients. The analysis results showed that the total effective rate (OR=3.70, 95％CI[2.58,5.30], P<0.00001) and cure rate (OR=2.40, 95％CI[1.86,3.10], P<0.00001), PASI score (OR=-2.65, 95％CI[-3.60,-1.70], P<0.00001), serum inflammatory cytokines(OR=-8.84,95％CI[-10.52,-7.16], P<0.00001), adverse reactions (OR=0.25, 95％CI[0.11,0.57], P=0.001) are superior to Acitretin Capsules. Statistics of the top 10 Chinese medicines in clinical used frequency are, in order, habitat, red peony root, paeonol, honeysuckle, comfrey, soil tuckahoe, salvia miltiorrhiza, buffalo horn, heliotrope, angelica. Conclusion: Based on the current evidence, the treatment of psoriasis with clearing heat and cooling blood as the mainstay of Chinese medicine alone or in combination with Acitretin Capsules can better improve the efficacy, and its mechanism may be related to reducing inflammation. Due to the limitation of the included literature, this conclusion needs to be further verified.