慢性肾脏病(chronic kidney disease,CKD)早期即可出现胰岛素抵抗(insulin resistance,IR)和高胰岛素血症,炎症、氧化应激、血管紧张素Ⅱ的激活、肥胖、活性维生素D缺乏、甲状旁腺功能亢进、贫血等因素可影响胰岛素分泌,诱发IR的发生发展。IR和高胰岛素血症又可通过几个途径直接或间接损伤肾脏。IR与慢性肾病互为因果,是近年的研究热点。 Early stages of chronic kidney disease (CKD) develop insulin resistance (IR) and hyperinsulinemia, inflammation, oxidative stress, activation of angiotensin II, obesity, active vitamin D deficiency, parathyroid Hyperthyroidism, anemia and other factors can affect insulin secretion, induced the occurrence and development of IR. In addition, IR and hyperinsulinemia can directly or indirectly damage the kidneys through several routes. IR and chronic kidney disease each other cause and effect, is a hot research in recent years.