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目的 探讨乳腺癌中CD44v6、p27蛋白表达的意义。方法 应用免疫组化S-P法检测65例乳腺癌中CD44v6、p27蛋白表达。结果 65例乳腺癌中CD44v6、p27蛋白表达总阳性率分别为58.4％、38.4％。CD44v6蛋白阳性表达率与乳腺癌组织学类型、腋淋巴结转移呈正相关(P<0.05,P<0.01),与预后呈负相关(P<0.01),与组织学分级无明显相关性(P>0.05);p27蛋白阳性表达与乳腺癌组织学类型、组织学分级及腋淋巴结转移呈负相关(P<0.05),与预后呈正相关(P<0.05)。结论 CD44v6、p27蛋白表达与乳腺癌浸润、转移及预后显著相关,检测乳腺癌中CD44v6、p27蛋白表达水平,对判断乳腺癌恶性程度、复发转移潜能,评估患者预后及术后选择合理治疗方案有一定参考价值。
Objective To investigate the significance of CD44v6 and p27 protein expression in breast cancer. Methods Immunohistochemical S-P method was used to detect the expression of CD44v6 and p27 in 65 cases of breast cancer. Results The positive rates of CD44v6 and p27 in 65 cases of breast cancer were 58.4% and 38.4% respectively. The positive rate of CD44v6 protein was positively correlated with histological type and axillary lymph node metastasis (P <0.05, P <0.01), but negatively correlated with prognosis (P <0.01), but not with histological grade ). The positive expression of p27 protein was negatively correlated with histological type, histological grade and axillary lymph node metastasis (P <0.05), and positively correlated with prognosis (P <0.05). Conclusion The expression of CD44v6 and p27 protein is significantly correlated with the infiltration, metastasis and prognosis of breast cancer. The expression of CD44v6 and p27 protein in breast cancer is significantly correlated with the degree of malignancy, the recurrence and metastasis potential, the prognosis of patients and the rational treatment options Certain reference value.