目的　为了解长期饮用矿物质强化豆粉对儿童骨质健康的影响 ,比较去植酸强化矿物质豆粉、去植酸未强化矿物质豆粉和强化矿物质牛奶的生物学效应。方法　选择 1 2～ 1 4岁男性儿童补充豆粉 2个月 ,比较强化豆粉、未强化豆粉和强化牛奶对儿童骨质转化指标血清骨钙素、尿Ⅰ型胶原C末端肽链 (CTx)和血清碱性磷酸酶 (b ALP)的影响。结果　经 2个月的补充干预实验 ,强化豆粉组、未强化豆粉组和强化牛奶组干预后血清骨钙素水平增加值分别为 (1 6 42± 1 1 2 5)、(1 8 86± 1 1 57)和 (1 3 81± 1 0 0 6) μg/L ;血清骨特异性碱性磷酸酶水平显著下降 ,干预后下降值分别为 (0 2 8± 0 40 )、(0 2 6± 0 35)和 (0 1 7± 0 2 8) μmol·s- 1 ·L- 1 ;尿CTx水平亦显著下降 ,干预后下降值分别为 (349 1±380 3)、(2 60 4± 41 2 4)和 (354 4± 40 4 7) μg/L。 结论　长期饮用矿物质强化豆粉可有效增加儿童的骨质积累 ,改善儿童的钙营养状况 Objective To understand the effect of long-term mineral fortified soy flour on bone health in children and to compare the biological effects of phytate fortified soy bean meal, phytate un-fortified mineral soy flour and fortified mineral milk. Methods Forty-two male children supplemented with soybean meal for 12 months were enrolled in this study. Serum levels of osteocalcin and urinary type Ⅰ collagen C-terminal peptide (CTx) were compared among fortified soybean meal, fortified soybean meal and fortified milk. ) And serum alkaline phosphatase (b ALP). Results After two months of supplemental intervention, the added value of serum osteocalcin levels after intervention with fortified soybean meal group, fortified soybean meal group and fortified milk group were (1 6 42 ± 1 1 2 5), (1 866 ± 1 1 57) and (1 3181 ± 1 0 0 6) μg / L, respectively. Serum bone-specific alkaline phosphatase levels were significantly decreased, with a decrease of (0 28 ± 0 40) and 6 ± 0 35) and (0 1 7 ± 0 2 8) μmol · s-1 · L-1, respectively. The urine CTx levels also decreased significantly after treatment, with the values ​​of 349 1 ± 380 3 and 2 60 4 respectively ± 41 2 4) and (354 4 ± 40 4 7) μg / L. Conclusion Long-term mineral fortified soybean meal can effectively increase children’s bone accumulation and improve children’s calcium status