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目的考察补充益生菌对儿童急性胰腺炎(PAP)的胃肠动力影响和可能机制。方法收集2012年2月至2015年10月在本院入住且确诊的PAP患儿106例,根据入院顺序随机分为2个组别:52例对照组和54例观察组。结果经2周的治疗,与对照组比,观察组的腹围减少明显,排气时间缩短,腹胀消失例数较多(P<0.05)。治疗前,两个组别的周血白蛋白、淀粉酶、内毒素和CRP无显著差异(P>0.05),治疗后,与对照组比,观察组的外周血白蛋白明显增高(P<0.05),淀粉酶、内毒素和CRP明显降低(P<0.05)。两个组别无死亡案例,与对照组比,观察组的显效、有效无显著差异(P>0.05),无效例数较少(P<0.05),总有效例较多(P<0.05)。与对照组比,观察组的住院天数明显缩短(P<0.05)。结论 PAP患儿肠应用益生菌可通过增强胃肠道动力达到治疗PAP的目的,但益生菌存在有疗效不确切和不良反应的文献报道,其安全性和有效性需要基于循证医学的研究验证。
Objective To investigate the effects of probiotics supplementation on gastrointestinal motility and its possible mechanism in children with acute pancreatitis (PAP). Methods A total of 106 PAP patients admitted to our hospital from February 2012 to October 2015 were selected and randomly divided into two groups according to admission sequence: 52 patients in the control group and 54 patients in the observation group. Results After 2 weeks of treatment, the abdominal circumference of the observation group was significantly decreased, the exhaust time was shortened, and the number of abdominal distension disappeared was more than that of the control group (P <0.05). Before treatment, there was no significant difference in serum albumin, amylase, endotoxin and CRP between the two groups (P> 0.05), after treatment, the peripheral blood albumin of the observation group was significantly higher than that of the control group ), Amylase, endotoxin and CRP were significantly lower (P <0.05). There were no death cases in both groups. Compared with the control group, there was no significant difference between the two groups (P> 0.05). There were fewer invalid cases (P <0.05) and more effective cases (P <0.05). Compared with the control group, the observation group hospitalization days were significantly shorter (P <0.05). Conclusions The use of probiotics in the intestine of PAP patients can achieve the purpose of treating PAP by increasing the motility of gastrointestinal tract. However, there are reports on the probiotic efficacy and adverse reactions of probiotics in the literature that the safety and efficacy of probiotics need to be verified by evidence-based medicine .