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人急性髓性白血病(AML)常起源于多能造血干细胞的恶性转化,致使细胞成熟阻滞于原粒或早幼粒阶段。AML研究中的核心问题是:在某些环境条件下,白血病细胞能否成熟,亦即白血病细胞的缺陷是否完全性的,外界条件能否使之发生改变。一些作者声称:在半固体琼脂或液体培养基中培养白血病患者细胞时所见到的分化正常的细胞,代表着白血病细胞的成熟。然而其他作者则未见到白血病细
Human acute myeloid leukemia (AML) often originates from the malignant transformation of pluripotent hematopoietic stem cells, resulting in cell maturation that is arrested in the granule or prospermal stage. The core question in AML research is: Under certain environmental conditions, whether leukemia cells can mature, that is, whether the defect of leukemia cells is complete, whether the external conditions can make it change. Some authors claim that the normal differentiated cells seen in cultured leukemic patients in semi-solid agar or liquid medium represent the maturation of leukemia cells. However, other authors did not see leukemia