论文部分内容阅读
目的 探讨影响神经母细胞瘤手术治疗的有关因素。方法 总结 16年中小儿神经母细胞瘤的治疗经验 ,着重对手术时机、手术方式等影响疗效的因素进行分析。结果 本组 10 8例中Ⅰ、Ⅱ期者仅占 12 .0 % (13/10 8) ;而Ⅲ、Ⅳ期者却占 87.9% (95 /10 8) ,其中Ⅲ期占 37.0 % (40 /10 8)、Ⅳ期占 5 0 .9% (5 5 /10 8)。手术组 88例 ,手术后 2年生存率Ⅰ期 10 0 %、Ⅱ期 81.8%、Ⅲ期 17.5 %、Ⅳ期14.3%。 8例延期手术完全切除肿瘤。结论 提高早期诊断率是改变预后的最直接方法 ,综合性手术治疗能显著提高进展期神经母细胞瘤的手术切除率。
Objective To investigate the factors that affect the surgical treatment of neuroblastoma. Methods To summarize the experience of treatment of neuroblastoma in children aged 16 years, focusing on the factors affecting the curative effect such as the timing of surgery and the surgical method. Results Of the 108 patients, stage I and stage II accounted for only 12.0% (13/10 8); patients in stages III and IV accounted for 87.9% (95 /10 8) of whom stage III accounted for 37.0 % (40 /10 8), IV stage accounted for 50.9% (5 5 /10 8). In the surgical group of 88 patients, the 2-year survival rate after surgery was 10% in stage I, 81.8% in stage II, 17.5% in stage III, and 14.3% in stage IV. Eight cases of delayed surgery completely resected the tumor. Conclusions Increasing the early diagnosis rate is the most direct method of changing the prognosis. Comprehensive surgical treatment can significantly improve the surgical resection rate of advanced neuroblastoma.