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Laurén(1965)将胃癌分为“肠型”及“弥漫型”两个主要类型。此后,作者们开始应用两型胃癌的分类,并对它们的组织发生、形态特点及其生物学行为进行了广泛研究,认为肠型胃癌在胃癌中占有重要位置。对于弥漫型胃癌(亦称胃型胃癌)的组织发生,目前多数学者认为主要系由胃粘膜腺颈部的干细胞发生。对于肠型胃癌的组织发生,许多作者认为与胃粘膜的肠上皮化生有着密切关系。近年一些作者发现肠化生上皮有几种不同的类型,并试图探讨“肠型胃癌”与肠化生类型的关系。
Laurén (1965) classified gastric cancer into two main types: “intestinal” and “diffuse.” Since then, the authors have begun to apply the classification of the two types of gastric cancer, and carried out extensive research on their histogenesis, morphological characteristics and biological behaviors. It is believed that intestinal type gastric cancer occupies an important position in gastric cancer. For the occurrence of diffuse gastric cancer (also known as stomach-type gastric cancer), most scholars currently believe that the main stem cells from the glands of the gastric mucosa occur. For the intestinal histogenesis, many authors believe that there is a close relationship with intestinal metaplasia of the gastric mucosa. In recent years, some authors have discovered several different types of intestinal metaplasia and attempted to explore the relationship between “intestinal gastric cancer” and the type of intestinal metaplasia.