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介绍2005年13省14市15家医院参加“浓度梯度法及琼脂稀释法监测医院感染耐药性项目[SEANIR项目(2005-2007)]”中的2400株菌监测结果,强调15家医院之间,不同菌株对不同药物的敏感率有明显差异;进而指出其3点原因——用药量、用药方法和医院感染控制等值得商榷的问题。同时介绍欧洲共同体多年研究抗菌药消耗与耐药率相关性取得的重大成就、方法学的先进性、严谨性及可比性;推荐我国一定要启动这类研究,以启动控制耐药率上升的宣传教育和行政措施的实施;最后介绍流行病学数学模型即抗菌药治疗过程中菌群变化的理论和结论,即如果能严格防止耐药株进入病房或医院,加上一系列有效感染控制及其他办法,一个医院或病房,可以在几个星期或1~2个月内消灭该耐药菌株。此外,目前社区的耐药株尚难以控制,需要更多投入与关注,且需要相当长的时间,甚至数十年才能消灭。
To introduce the results of the monitoring of 2,400 strains of bacteria in the surveillance of nosocomial drug resistance by the concentration gradient method and the agar dilution method [SEANIR project (2005-2007)] in 15 hospitals in 13 provinces and cities in 2005, emphasizing the monitoring results among 15 hospitals , Different strains of different drug sensitivity were significantly different; then pointed out that the three reasons - the amount of medication, medication and hospital infection control is questionable. In the meantime, we will also introduce the major achievements made by the European Community in studying the correlation between antimicrobial consumption and drug resistance for many years, and the advancedness, rigor and comparability of methodologies. We recommend that we initiate such studies in order to launch a campaign to control the rise in drug resistance Education and administrative measures. Finally, the theory and conclusion of the epidemiological mathematical model that flora changes during the treatment of antimicrobial agents are introduced. If the drug resistant strains can be strictly prevented from entering the ward or hospital and a series of effective infection control and other Approach, a hospital or ward, can eradicate the drug-resistant strain in weeks or 1-2 months. In addition, drug-resistant strains in the community are still beyond our control and require more input and attention and take a considerable amount of time, or even decades, to be eliminated.