【摘 要】
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Toll-like receptors (TLRs) are well-known as patternrecognition receptors in the immune system for recognizing pathogen-associated and damage-associated molecular patterns [1].TLRs play an essential role in the innate and adaptive immune responses.To date
【机 构】
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Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow Universit
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Toll-like receptors (TLRs) are well-known as patternrecognition receptors in the immune system for recognizing pathogen-associated and damage-associated molecular patterns [1].TLRs play an essential role in the innate and adaptive immune responses.To date,10 functional TLRs have been identified in humans (TLR1-TLR10) and 12 in mice (TLR1-TLR9 and TLRll-TLR13) [1].TLRs are evolutionarily conserved type Ⅰ transmembrane proteins and comprise an ectodomain characterized by leucine-rich repeats mediating the recognition of ligands,a transmembrane region,and cytosolic Toll-interleukin (IL)-1 receptor domains that activate the downstream signaling pathways [1].
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