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目的探讨MMP-14与宫颈癌临床病理因子的关系。方法对42例宫颈癌MMP-14的表达进行免疫组化检测。结果MMP-14在正常宫颈组织及宫颈癌中的表达差异显著,不同组织分型及FIGO分期宫颈癌中MMP-14的表达无差异性,MMP-14在淋巴结转移组中的表达明显高于无淋巴结转移组。结论MMP-14与宫颈癌的侵袭有关,有利于判定宫颈癌的生物学行为和预后。
Objective To investigate the relationship between MMP-14 and clinicopathological factors in cervical cancer. Methods 42 cases of cervical cancer MMP-14 expression was detected by immunohistochemistry. Results The expression of MMP-14 in normal cervical tissue and cervical cancer was significantly different. There was no difference in the expression of MMP-14 between different tissues and FIGO staging cervical cancer. The expression of MMP-14 in lymph node metastasis was significantly higher than that without Lymph node metastasis group. Conclusion MMP-14 is related to the invasion of cervical cancer, which is helpful to determine the biological behavior and prognosis of cervical cancer.