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目的观察埃索美拉唑联合莫沙必利治疗胃食管反流病的疗效。方法将我院2009年1月～2010年11月收治的78例胃食管反流病患者遵照知情同意原则随机分为两组,对照组38例采用奥美拉唑联合莫沙必利治疗,观察组40例采用埃索美拉唑联合莫沙必利治疗,对两组的临床疗效及不良反应发生情况进行比较。结果观察组的总有效率为97.5%,对照组总有效率为78.9%,两组间差异有统计学意义(x2=4.8795,P<0.05);两组均无严重不良反应发生。结论埃索美拉唑联合莫沙必利治疗胃食管反流病获得满意的临床疗效,且安全性较高,值得推广应用。
Objective To observe the efficacy of esomeprazole combined with mosapride in the treatment of gastroesophageal reflux disease. Methods 78 cases of gastroesophageal reflux disease patients admitted to our hospital from January 2009 to November 2010 were randomly divided into two groups according to the principle of informed consent. The control group, 38 cases were treated with omeprazole combined with mosapride, and observed Group 40 cases were treated with esomeprazole combined with mosapride, the clinical efficacy and adverse reactions of the two groups were compared. Results The total effective rate was 97.5% in the observation group and 78.9% in the control group. The difference between the two groups was statistically significant (x2 = 4.8795, P <0.05). No serious adverse reactions occurred in both groups. Conclusion Esomeprazole combined with mosapride in the treatment of gastroesophageal reflux disease has a satisfactory clinical efficacy, and high safety, it is worth promoting the application.