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β-葡萄糖苷酸酶(以下简称β-GU),是组织细胞内溶酶体中水解酶类的一种。具有水解固醇葡萄糖醛酸和酸性粘多糖的生理功能。它广泛存在干哺乳类组织中。除了肝、脾、肾上腺外,胃肠道粘膜内含量也较丰富。Piper等人发现胃癌患者胃液中的β-GU活力远较正常人或非恶性肿瘤的胃肠道疾病患者的β-GU的活力为高。Kim等人指出测定胃液中的β-GU活力,有诊断胃癌的实际价值。国内也有类似报告,并认为对早期胃癌的发现有一定价值。有关癌组织内β-GU的定位研究,国外已有报道。Monis等人对32个恶性肿瘤病
Β-glucuronidase (hereinafter abbreviated as β-GU) is a type of hydrolase in lysosomes in tissue cells. Has the physiological functions of hydrolytic sterol glucuronic acid and acid mucopolysaccharides. It is widely found in dry mammals. In addition to the liver, spleen, adrenal glands, the gastrointestinal mucosa is also rich in content. Piper et al. found that the β-GU activity in the gastric juice of patients with gastric cancer was far higher than that of patients with gastrointestinal diseases in normal or non-malignant tumors. Kim et al. pointed out that the determination of β-GU activity in gastric juice has the practical value of diagnosing gastric cancer. There are similar reports in China and they believe that there is a certain value in the discovery of early gastric cancer. Localization of β-GU in cancer tissues has been reported abroad. Monis et al. on 32 malignancies