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猪苓提取物腹腔给药,对小鼠移植性肉瘤180均有明显的抑制作用。经提取物治疗的荷瘤小鼠中,约有6～7%肿瘤完全消退,而对照组未见自然消退。对肿瘤完全消退的小鼠,在1个月和半年后再次接种肿瘤细胞,经1个月的观察均不生长肿瘤。猪苓提取物,经腹腔注射、静脉注射及灌胃等不同途径给药,在一定剂量下均能抑制肿瘤的生长,但以腹腔及静脉给药的作用较强,口服效果较差,给药量也大。七个不同产地的猪苓提取物对小鼠腹水型肉瘤180均有较显著抑制作用。猪苓提取物预防给药对小鼠腹水型肉瘤180的生长有抑制作用。接种后静脉迟缓给药可控制肿瘤生长,而腹腔迟缓给药(10毫克/公斤)还没看到显著效果。猪苓提取物与化疗药合用不影响化疗药的疗效。
The intraperitoneal administration of Polyporus umbellatus extract significantly inhibited the transplanted sarcoma 180 in mice. In the tumor-bearing mice treated with the extract, about 6 to 7% of the tumors completely disappeared, while the control group showed no natural regression. In mice completely regressed with tumor, tumor cells were inoculated again one month and six months later, and no tumors were observed after one month of observation. The swine fever extract, administered by intraperitoneal injection, intravenous injection and intragastric administration, can inhibit the growth of tumors at a certain dose, but the effect of intraperitoneal and intravenous administration is stronger, and the oral administration effect is poor. The amount is also large. The extracts from seven different origins of swine fever showed a significant inhibitory effect on mouse ascites sarcoma 180. The preventive administration of classical swine fever extract inhibited the growth of mouse ascites sarcoma 180. Intravenous administration after vaccination can control tumor growth, whereas no significant effect has been seen with intraperitoneal delayed administration (10 mg/kg). The combination of classical swine fever extract and chemotherapeutic drugs does not affect the efficacy of chemotherapy drugs.