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目的 观察缺血性脑血管病（ＩＣＶＤ）患者血清白细胞介素－８（ＩＬ－８）水平的变化。方法 采用双抗体夹心间接ＥＬＩＳＡ法，测定４５例ＩＣＶＤ患者（观察组）及２０名正常人（对照组）血清中ＩＬ－８水平。结果 观察组血清ＩＬ－８水平显著高于正常对照组（Ｐ＜０．０５）。观察组中发病１周内血清ＩＬ－８水平较发病１周后血清ＩＬ－８水平高（Ｐ＜０．０５）；大面积脑梗死者较小面积脑梗死者高（Ｐ＜０．０５）。结论ＩＬ－８的变化与脑缺血的病程及缺血面积大小有关，与前者呈负相关，与后者呈正相关。脑缺血损伤引起ＩＬ－８的表达，而ＩＬ－８水平的升高又加重脑损伤的程度。
Objective To observe the changes of serum interleukin-8 (IL-8) in patients with ischemic cerebrovascular disease (ICVD). Methods Serum levels of IL-8 in 45 patients with ICVD (observation group) and 20 normal persons (control group) were determined by double antibody sandwich indirect ELISA. Results The level of serum IL-8 in the observation group was significantly higher than that in the normal control group (P <0.05). The level of serum IL-8 in the observation group within 1 week after onset was higher than that in the 1 week after onset (P <0.05); the area of cerebral infarction in the large area of cerebral infarction was higher (P <0.05) . Conclusion The change of IL-8 is related to the course of cerebral ischemia and the size of ischemic area, negatively correlated with the former and positively correlated with the latter. Cerebral ischemic injury leads to the expression of IL-8, and the increased level of IL-8 aggravates the degree of brain injury.