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２０例颊粘膜鳞癌患者分为单纯手术组和化疗加手术组。在手术标本上自肿瘤的肉眼边界向手术切缘行放射状取材，作ＨＥ及Ａｇ－ＮＯＲｓ染色。１０例正常颊粘膜作对照。结果提示：癌细胞自癌灶肉眼边界向周围粘膜下组织浸润的宽度可达９．９９ｍｍ，明显大于粘膜浸润的长度；对诱导化疗有效的颊粘膜鳞癌，侵润能力降低；颊鳞癌浸润基底的深度为０．３１～２．３２ｍｍ；正常人颊粘膜与鳞癌组织、癌旁０．５ｃｍ处粘膜上皮的Ａｇ－ＮＯＲｓ颗粒数目及大小有显著差异，而与单纯手术组癌旁１．５ｃｍ、化疗加手术组癌旁１．０ｃｍ处粘膜上皮无明显差异，可考虑作为手术的安全切缘。
Twenty cases of buccal squamous cell carcinoma were divided into simple operation group and chemotherapy plus operation group. In the surgical specimens from the naked eye border to the surgical margin of the line radial drawing, for HE and Ag-NORs staining. Ten cases of normal buccal mucosa as a control. The results suggest that the width of cancer cells infiltrating from the macroscopic border of the tumor to the surrounding submucosal tissue is up to 9.99mm, which is obviously longer than the length of mucosal infiltration. The cheek squamous cell carcinoma effective in inducing chemotherapy reduces the infiltration capacity, The depth of the basal lamina was 0.31-2.32mm. There were significant differences in the number and size of Ag-NORs in normal mucosa, squamous cell carcinoma and mucosal epithelium at 0.5cm adjacent to the tumor, 5cm, chemotherapy and surgery group adjacent mucosal epithelial 1.0cm no significant difference, can be considered as surgical margin of safety.