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目的对比研究食管癌放疗联合PF方案静脉化学疗法之时辰化学疗法与常规化学疗法,观察其疗效、临床不良反应的情况。方法所有病例均行食管癌癌放疗,辅以PF方案静脉化学疗法。静脉化学疗法分为时辰化学疗法与常规化学疗法2组,统计最常见不良反应发生率,治疗后复查以评价肿瘤控制情况。结果时辰化学疗法对最常见不良反应均有不同程度的减轻,而有效率则有一定程度的提高,两组有显著性差异。结论应用时辰化学疗法,可以在两方面受益,一是减少不良反应,提高生活质量;二是可以提高治疗效果。
Objective To compare the chrono-chemotherapy and conventional chemotherapy of esophageal cancer radiotherapy combined with PF regimen intravenous chemotherapy, observe the efficacy and clinical adverse reactions. Methods All patients underwent radiotherapy for esophageal cancer and supplemented with PF chemotherapy. Venous chemotherapy was divided into two groups: chronochemotherapy and conventional chemotherapy. The incidence of the most common adverse reactions was counted and reviewed after treatment to evaluate tumor control. Results The chrono-chemotherapy reduced the most common adverse reactions to varying degrees, while the effective rate increased to a certain extent. There was a significant difference between the two groups. Conclusion The use of chrono-chemotherapy can benefit in two aspects. First, it reduces adverse reactions and improves quality of life. Second, it can improve the therapeutic effect.