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目的:探讨紫杉醇和顺铂方案化疗联合放疗序贯治疗中晚期老年宫颈癌患者的临床疗效和不良反应。方法:对51例老年局部中晚期宫颈癌患者采用紫杉醇和顺铂化疗序贯放疗,观察近期临床疗效和不良反应。结果:51例患者完全缓解38例,部分缓解10例,进展3例,有效率94.12%。病理类型中鳞癌近期治疗有效率93.48%,腺癌有效率100.00%;临床分期Ⅱb期有效率100.00%,Ⅲa期有效率92.86%,Ⅲb期有效率71.43%;病理类型和临床分期间差异无统计学意义(P>0.05)。主要不良反应为中性粒细胞下降和放射性直肠反应。结论:紫杉醇和顺铂方案序贯放疗可提高中期宫颈癌患者的生存率,不良反应少,可作为局部中期宫颈癌患者的理想选择之一。
Objective: To investigate the clinical efficacy and side effects of paclitaxel and cisplatin regimen combined with radiotherapy sequential treatment of advanced cervical cancer patients. Methods: 51 cases of elderly patients with locally advanced cervical cancer using paclitaxel and cisplatin chemotherapy sequential radiotherapy to observe the short-term clinical efficacy and adverse reactions. Results: 51 patients were completely relieved 38 cases, partial remission in 10 cases, 3 cases of progress, the effective rate was 94.12%. The effective rate of squamous cell carcinoma was 93.48% and adenocarcinoma was 100.00%. The effective rate of clinical stage Ⅱb was 100.00%, the effective rate of stage Ⅲa was 92.86%, the effective rate of stage Ⅲb was 71.43%. The difference of pathological type and clinical stage was Statistical significance (P> 0.05). The main adverse reactions were neutropenia and radiation rectal reaction. Conclusions: Sequential radiotherapy with paclitaxel and cisplatin can improve the survival rate of patients with medium-term cervical cancer with less adverse reactions and can be used as an ideal choice for local cervical cancer patients.