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目的 研究p53胃粘膜上皮不典型增生、早期胃癌及进展期胃癌中的表达及临床意义。方法 使用抗P53蛋白的单克隆抗体Do-7对196例胃癌,59例胃粘膜不典型增生,37例早期胃癌组织p53的表达进行免疫组化研究。结果 p53在轻度不典型增生,中度不典型增生,重度不典型增生,早期胃癌,进展期胃癌表达率分别为6.7％、10.5％、48.0％、48.6％、50.5％。结论 胃粘膜上皮轻度、中度不典型增生表达较低,而在重度不典型增生,早期胃癌和进展期胃癌中有较高表达。表明p53在胃粘膜上皮癌发生、发展中起作用,且p53异常表达是胃癌发生的早期事件,与胃癌发生有关。
Objective To study the expression and clinical significance of p53 gastric mucosa epithelial dysplasia, early gastric cancer and advanced gastric cancer. Methods Immunohistochemical study was performed on the expression of p53 in 196 cases of gastric cancer, 59 cases of gastric dysplasia, and 37 cases of early gastric cancer using monoclonal antibody Do-7 against P53 protein. Results The expression rates of p53 in mild dysplasia, moderate dysplasia, severe dysplasia, early gastric cancer and advanced gastric cancer were 6.7%, 10.5%, 48.0%, 48.6%, and 50.5%, respectively. Conclusion The expression of mild and moderate dysplasia in gastric epithelium is low, but it is highly expressed in severe dysplasia, early gastric cancer and advanced gastric cancer. It is indicated that p53 plays a role in the occurrence and development of gastric epithelial carcinoma, and abnormal expression of p53 is an early event of gastric cancer and is related to the occurrence of gastric cancer.