The formation of a filter cake during the filtration of a suspension with non-spherical particles is studied using a multi-sphere model in a simulation that couples the discrete element method with computa-tional fluid dynamics.The implementation of the coupling with a drag model that considers orientation,sphericity,and the presence of surrounding particles for non-spherical particles is tested for single parti-cles and suspensions by comparing the terminal velocities with empirical results.Phenomena predicted in the simulations,such as the presence or absence of initial oscillations and changes in the orientation of a particle,are consistent with experimental observations reported in the literature.The variation in the void fraction of a filter cake with respect to the particle sphericity is obtained and compared with experimental trends reported in the literature.Furthermore,complex interdependencies of the parti-cle sphericity,void fraction,and pressure drop of a filter cake for a wide range of fluid conditions are investigated.