目的比较纯品花色苷、黑米花色苷对高脂血症人群体内氧化应激水平的影响。方法选取高脂血症志愿者90名,按性别、年龄、收入、教育、患病服药情况匹配后随机分为黑米花色苷、纯品花色苷、安慰剂三组,每组30例,分别给予对应胶囊,每日2次,每次2粒(黑米花色苷提取物200 mg/d,纯品花色苷320 mg/d,淀粉糊精1000 mg/d),连续12w,于干预前后进行体格测量、膳食调查,并留血、尿样本检测氧化应激指标。结果干预前后各组每日膳食摄入量、营养素摄入量及供能百分比差异无统计学意义(P>0.05);黑米花色苷组干预后血清TC、TG较干预前明显降低(P<0.05);纯品花色苷组干预后血清TC、LDL较干预前明显降低(P<0.05),HDL与干预前比较明显升高(P<0.05);安慰剂组血脂各项指标干预前后无明显变化(P>0.05)。干预后纯品花色苷组的T-AOC水平较干预前以及与安慰剂组比较明显升高(P<0.05);黑米花色苷组干预后及与安慰剂组比较,差异无统计学意义(P>0.05)。干预后纯品花色苷及黑米花色组血清总SOD活性比干预前明显升高(P<0.05);亦明显高于安慰剂组(P<0.05)。三组间干预前后尿8-异前列烷浓度差异无统计学意义(P>0.05)。结论黑米花色苷与纯品花色苷具有不同程度改善高脂血症人群血脂及体内氧化应激水平的作用。 Objective To compare the effects of pure anthocyanins and black rice anthocyanins on oxidative stress in hyperlipidemic subjects. Methods Ninety hyperlipidemic volunteers were selected and randomly divided into three groups: black rice anthocyanin, pure anthocyanin and placebo, according to the sex, age, income, education and prevalence. Each group had 30 cases The corresponding capsules were given twice a day for 2 capsules (200 mg / d of black rice anthocyanin extract, 320 mg / d of pure anthocyanins and 1000 mg / d of starch dextrin) for 12 consecutive days before and after the intervention Physical measurements, dietary surveys, and blood, urine samples were tested for oxidative stress. Results There were no significant differences in daily dietary intake, nutrient intake and energy supply percentage between the groups before and after intervention (P> 0.05). The levels of TC and TG in serum of the black rice anthocyanin group were significantly lower than those before the intervention (P < 0.05). The levels of serum TC and LDL in pure anthocyanins group were significantly lower than those before intervention (P <0.05), and HDL levels were significantly higher than those before intervention (P <0.05). There was no significant difference between the placebo group and before treatment Change (P> 0.05). After intervention, the T-AOC level in pure anthocyanins group was significantly higher than that in placebo group and placebo group (P <0.05). There was no significant difference between the intervention group and the placebo group P> 0.05). After intervention, the serum total SOD activity of pure anthocyanins and black rice color group was significantly higher than that before intervention (P <0.05), and also significantly higher than that of placebo group (P <0.05). There was no significant difference in urinary 8-isoprostane concentration between the three groups before and after intervention (P> 0.05). Conclusion The effect of anthocyanins of black rice and pure anthocyanins on the level of blood lipid and oxidative stress in hyperlipidemia patients is different.