血管发生是骨修复早期的关键环节之一,功能性微血管网的形成对骨组织再生至关重要,可促进血管内皮细胞与成骨细胞在信号通路上的相互作用,有利于后者在骨缺损区的募集和分化。骨组织再生是一个多因素共同协调的复杂信号通 Angiogenesis is one of the key early stages of bone repair. The formation of functional microvascular network is crucial to the regeneration of bone tissue, which can promote the interaction of vascular endothelial cells and osteoblasts in the signaling pathway, which is beneficial to the latter in the bone defect District recruitment and differentiation. Bone tissue regeneration is a multi-factor coordination of complex signals