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对小鼠采用4种光照方案以及热板测痛法,证明生理基础痛阈和哌替啶的镇痛效力均有明显的光暗差异,在标准光照周期中,二者的峰值均出现于黑暗时相,光照可使痛阈降低。摘除松果体后,上述昼夜节律消失。给小鼠注射褪黑激素后小剂量哌替啶的镇痛作用增强。这些结果提示,哌替啶镇痛作用的昼夜节律受松果体褪黑激素的调节,并可能与其促进内源性阿片肽的释放有关。
Four kinds of illumination scheme and hot plate method were applied to mice, which showed that there were obvious light and dark differences between the base pain threshold of physiology and the analgesic efficacy of meperidine. During the standard photoperiod, both peak appeared in the dark Time, light can reduce the pain threshold. After removing the pineal body, the circadian rhythm disappears. The analgesic effect of small doses of pethidine was enhanced after mice were injected with melatonin. These results suggest that the circadian rhythm of pethidine analgesia is regulated by pineal melatonin and may be related to its contribution to the release of endogenous opioid peptides.