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目的:探讨EphA2基因在大肠腺癌转移中的作用机制。方法:采用免疫组化(SP)技术对126例大肠腺癌组织和相应正常大肠黏膜组织中EphA2蛋白表达进行检测;并同时测定血清ICAM-1和VCAM-1。结果:EphA2蛋白表达在126例癌组织中明显高于正常大肠黏膜组织(P<0.001),EphA2蛋白表达阳性患者中血清ICAM-1和VCAM-1均高于EphA2表达阴性患者,亦高于正常对照组,差异有统计学意义(P<0.05)。结论:EphA2基因与大肠腺癌的发生、肿瘤细胞的迁移和浸润能力相关,其调节肿瘤细胞转移的机制可能与ICAM-1和VCAM-1有关。
Objective: To explore the mechanism of EphA2 gene in the metastasis of colorectal adenocarcinoma. Methods: The expression of EphA2 protein in 126 cases of colorectal adenocarcinoma and its corresponding normal colorectal mucosa was detected by immunohistochemistry (SP), and the levels of serum ICAM-1 and VCAM-1 were measured simultaneously. Results: The expression of EphA2 protein in 126 cases of cancerous tissues was significantly higher than that of normal colorectal mucosa (P <0.001). The levels of ICAM-1 and VCAM-1 in serum of EphA2-positive patients were significantly higher than those of EphA2-negative patients Control group, the difference was statistically significant (P <0.05). CONCLUSION: EphA2 gene is associated with the occurrence of colorectal adenocarcinoma, tumor cell migration and invasion, and the mechanism of its regulation of tumor cell metastasis may be related to ICAM-1 and VCAM-1.