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目的探讨黑斑胃肠道息肉病(PJS)息肉病理性质与癌变的关系。方法本文采用回顾性研究,研究对象分为病例组与对照组。病例组为18例PJS患者的息肉组织;对照组为36例非PJS患者的息肉或癌组织。PJS患者中4例癌变患者、14例结肠镜检与复查患者的息肉组织,按大、中、小选择息肉组织做标本,并在其内、中、外部各取组织3块,共制作586个病理切片,与其他大肠癌及其他疾病的息肉组织比较,由院内两位病理专家进行单盲对比阅片,确定病理性质,并进行采用Kappa一致性分析和统计学检验。结果所检息肉均为腺瘤性质,癌变发生于腺瘤性息肉;经统计检验后结果显示PJS患者与其他大肠癌或其他肠息肉病理性质无差异。结论本组PJS病例肠息肉均为腺瘤性质,是该病大肠癌发生的根本原因;这很可能为PJS患者息肉癌变的另一途径,即:腺瘤-癌变的发展过程。
Objective To investigate the relationship between pathological features and carcinogenesis of polyps of black spot gastrointestinal polyposis (PJS). Methods The retrospective study was used in this study. The subjects were divided into case group and control group. The case group was polyp tissue from 18 PJS patients and the control group was polyp or cancerous tissue from 36 non-PJS patients. PJS patients in 4 cases of cancer patients, 14 cases of colonoscopy and review of the polyps in patients with large, medium and small selection of polyps specimens, and in its internal and external organizations take 3, a total of 586 Pathology, and other colorectal cancer and other diseases compared with polyps, the hospital by two pathologists compared the single blind read, determine the pathological nature of the use of Kappa consistency analysis and statistical tests. The results of the detected polyps were adenoma, carcinogenesis occurred in adenomatous polyps; the results of statistical tests showed no difference between PJS patients and other colorectal cancer or other intestinal polyps pathological properties. Conclusions The intestinal polyps of PJS cases in this group are all adenoma, which is the basic reason for the occurrence of colorectal cancer in this disease. It is likely to be another way of polyposis carcinogenesis in PJS patients, namely, the development of adenoma-carcinogenesis.