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本文报道61名2～11月龄(平均年龄4.3个月)婴儿对Vero细胞脊髓灰质炎灭活疫苗的耐受性和血清免疫应答。Vero细胞是用工业规模的微载体系统培养的。每人份Ⅰ、Ⅱ和Ⅲ型灭活疫苗的D抗原浓度分别为40、8和32单位。每个婴儿注射3次IPV,每隔1个月注射1次,同时注射DTP。于注射前、第3次注射前和第3次注射后30天采血标本。61名婴儿总共注射疫苗183次,观察到6次注射部位局部反应,
This article reports the tolerability and serum immune response of 61 infants aged 2-11 months (mean age 4.3 months) to the Vero cell polio inactivated vaccine. Vero cells are cultured on an industrial scale microcarrier system. The D antigen concentration of inactivated vaccine of type I, II and III per person was 40, 8 and 32 units respectively. IPV was administered 3 times per infant and injected once every 1 month with DTP. Blood samples were taken prior to injection, before the third injection, and 30 days after the third injection. A total of 61 infants were vaccinated 183 times in total, 6 local reactions were observed at the injection site,