目的　探讨新生儿急性肾功能衰竭 (ARF)过程中血、尿表皮生长因子 (EGF)的变化及其意义。方法　采用放射免疫分析法 ,测定 17例对照组新生儿和 31例ARF新生儿少尿期、多尿期和恢复期血清和尿EGF水平。结果　肾衰组在少尿期和多尿期血清和尿EGF均显著下降 ,恢复期血清和尿EGF水平恢复至正常。肾衰组少尿期和恢复期尿EGF与同期尿素氮 (BUN)、血肌酐 (SCr)水平呈显著负相关。结论　在新生儿ARF过程中血、尿EGF呈先下降后上升变化趋势 ,反映了肾脏的损害及修复过程 Objective To investigate the changes of blood and urine epidermal growth factor (EGF) in neonates with acute renal failure (ARF) and its significance. Methods Radioimmunoassay was used to detect the levels of serum and urinary EGF in the oliguria, polyuria and convalescent of 17 neonates with ARF and 31 ARF neonates. Results Serum and urinary EGF levels were significantly decreased in the renal failure group during oliguria and polyuria, and serum and urinary EGF levels recovered to normal during recovery. There was a significant negative correlation between urinary EGF and urine urea nitrogen (BUN) and serum creatinine (SCr) in renal failure group during oliguria and convalescence. Conclusion In the neonatal ARF process, blood and urine levels of EGF first increase and then decrease, reflecting the damage and repair process of the kidney