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目的评价大剂量左氧氟沙星治疗常见急性呼吸系统感染的临床疗效及安全性。方法分别口服和静脉滴注左氧氟沙星500mg,1次/d,对呼吸系统常见的细菌感染189例进行临床观察,评价其疗效与安全性。结果口服(96例)与静脉滴注(93例)给药的临床有效率分别为96.87%和98.92%,细菌清除率分别为97.92%和98.91%,疗程分别为(7.06±2.25)d和(6.56±2.97)d,不良反应发生率分别为6.25%和8.60%。不良反应多为皮肤和胃肠道反应,但极轻微,对治疗无影响,停药后反应消失。结论大剂量左氧氟沙星口服或静脉滴注给药起效快、疗效高,未见明显不良反应。
Objective To evaluate the clinical efficacy and safety of high-dose levofloxacin in the treatment of common acute respiratory infections. Methods Levofloxacin was administered orally and intravenously (n = 500) once a day for 189 cases. The clinical efficacy and safety of levofloxacin were evaluated in 189 cases of common bacterial infections in the respiratory system. Results The clinical efficacies of oral administration (96 cases) and intravenous drip infusion (93 cases) were 96.87% and 98.92%, respectively. The bacterial clearance rate was 97.92% and 98.91% respectively. The courses of treatment were (7.06 ± 2.25) d and 6.56 ± 2.97) d, the incidence of adverse reactions were 6.25% and 8.60%. Adverse reactions were mostly skin and gastrointestinal reactions, but very slight, no effect on treatment, after stopping the reaction disappeared. Conclusion High-dose levofloxacin oral or intravenous infusion of fast onset, high efficacy, no significant adverse reactions.