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目的:探讨液基薄层细胞制片术(TCT)在宫颈癌早期诊断中的价值。方法:将某单位2167例妇女随机分成两组。实验组1083例,采用液基薄层细胞制片技术;对照组1084例,采用传统的巴氏涂片术。对两组细胞学诊断阳性病例均行阴道镜活检和组织病理学诊断,并对两组检测结果进行统计学分析。结果:实验组细胞学LSIL和HSIL的检出率分别为7.41%和3.61%,与活检组织学诊断比较,符合率分别为96.25%(77/80)和92.31%(36/39);对照组细胞学LSIL和HSIL的检出率分别为3.89%和1.85%,与活检组织学诊断比较,符合率分别为92.86%(39/42)和90.00%(18/20)。以组织学诊断结果为金标准,两组组织学符合率比较,无显著性差异(P>0.05),两组阳性病例检出率比较,有显著性差异(P<0.05)。结论:液基薄层细胞制片对宫颈癌早期病变检出阳性率较高,与组织学检查的诊断符合率相一致,是临床宫颈癌早期筛查的好方法。
Objective: To investigate the value of liquid-based thin-slice cytometry (TCT) in the early diagnosis of cervical cancer. Methods: A total of 2167 women were divided into two groups. 1083 cases of experimental group, the use of liquid-based thin-layer cell preparation technology; control group, 1084 cases, the use of traditional Pap smear. Colposcopy biopsy and histopathological diagnosis of positive cases of cytology in both groups, and the two groups of test results were statistically analyzed. Results: The cytological detection rates of LSIL and HSIL in the experimental group were 7.41% and 3.61%, respectively. The coincidence rates were 96.25% (77/80) and 92.31% (36/39), respectively. The control group The positive rates of cytology LSIL and HSIL were 3.89% and 1.85%, respectively, which were 92.86% (39/42) and 90.00% (18/20), respectively. Histological diagnostic results as the gold standard, the two groups of histological coincidence rate, no significant difference (P> 0.05), positive rate of detection of the two groups were significantly different (P <0.05). CONCLUSION: The positive rate of liquid-based thin-section cells in detecting early lesions of cervical cancer is high, consistent with the diagnostic accuracy of histological examination, which is a good method for early screening of cervical cancer.