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目的:探讨高血压患者年龄、病程及动态动脉硬化指数(AASI)与尿微量白蛋白(UmAIb)的关系。方法:将2008年至2010年广东药学院附属第一医院收治的108例原发性高血压患者,按年龄、病程及AASI分组,检测不同组别患者的UmAIb浓度,分析年龄、病程及AASI与UmAIb的关系。结果:不同年龄、病程、AASI组间患者UmAIb比较,差异有统计学意义(F=32.83、59.18、t=7.85,P<0.001);相关分析结果显示,年龄、病程及AASI与UmAIb呈正相关(r=0.7906、、0.7490、0.6999,P<0.001)。偏相关分析结果表明,年龄、病程及AASI与UmAlb的相关系数均变小,≥60岁患者的AASI与UmAlb相关性无统计学意义(r=0.088,P=0.638)。结论:UmAlb随年龄及病程的增加而增加,AASI是预测高血压患者早期肾脏损害的有用指标。
Objective: To investigate the relationship between age, course of disease, dynamic arteriosclerosis index (AASI) and urinary microalbumin (UmAIb) in patients with hypertension. Methods: 108 patients with essential hypertension admitted to the First Affiliated Hospital of Guangdong University of Pharmacy from 2008 to 2010 were divided into groups according to their age, course of disease and AASI. The concentrations of UmAIb in different groups were detected. Age, course of disease, AASI and UmAIb relationship. Results: There was a significant difference in UmAIb between AASI group and different age groups (F = 32.83,59.18, t = 7.85, P <0.001). Correlation analysis showed that age, course of disease and AASI were positively correlated with UmAIb r = 0.7906, 0.7490, 0.6899, P <0.001). Partial correlation analysis showed that age, duration of disease and the correlation coefficient of AASI and UmAlb became smaller. There was no significant correlation between AASI and UmAlb in patients ≥60 years of age (r = 0.088, P = 0.638). Conclusion: UmAlb increases with age and course of disease, and AASI is a useful indicator of early renal damage in hypertensive patients.