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目的：介绍脂质体经皮给药的研究进展情况，为研制此类制剂提供参考。方法：根据近年文献，从脂质体经皮给药的特点、促透机制、动物实验与临床观察等方面进行论述。结果：脂质体可促进高分子药物的透皮吸收，产生全身治疗作用，也可加强药物的局部作用，提高生物利用度，降低副作用。结论：脂质体经皮给药是一种有发展前途的给药方式。
OBJECTIVE: To introduce the research progress of transdermal delivery of liposomes and provide reference for the preparation of such preparations. Methods: According to the literature in recent years, the characteristics of transdermal delivery of liposomes, mechanism of perviousness, animal experiments and clinical observation were discussed. Results: Liposomes can promote the transdermal absorption of macromolecular drugs and produce systemic therapeutic effects. It can also enhance the local effects of drugs, improve the bioavailability and reduce the side effects. Conclusion: Transdermal administration of liposomes is a promising way of delivery.