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目的探讨血清胱抑素C(Cys C)和同型半胱氨酸(Hcy)在2型糖尿病肾病患者中的检测意义。方法 82例糖尿病患者分为观察组(早期糖尿病肾病42例)和对照组(单纯糖尿病40例),同时选取50例在本院体检健康者作为健康组。测定三组血清胱抑素C和同型半胱氨酸水平。结果观察组和对照组血清胱抑素C和同型半胱氨酸水平均高于健康组,差异具有统计学意义(P<0.05);观察组血清胱抑素C和同型半胱氨酸水平高于对照组,差异具有统计学意义(P<0.05)。结论早期糖尿病肾病患者血清胱抑素C和同型半胱氨酸水平均升高,联合检测可为临床对糖尿病肾病的早期诊断提供帮助。
Objective To investigate the significance of serum cystatin C (Cys C) and homocysteine (Hcy) in type 2 diabetic nephropathy. Methods 82 cases of diabetic patients were divided into observation group (42 cases of early diabetic nephropathy) and control group (40 cases of simple diabetes mellitus). Meanwhile, 50 healthy people in our hospital were selected as healthy group. Three groups of serum cystatin C and homocysteine levels were measured. Results The levels of serum cystatin C and homocysteine in the observation group and the control group were significantly higher than those in the healthy group (P <0.05). The levels of serum cystatin C and homocysteine in the observation group were significantly higher than those in the control group In the control group, the difference was statistically significant (P <0.05). Conclusions Serum levels of cystatin C and homocysteine in patients with early diabetic nephropathy are elevated. Combined detection may be helpful in the early diagnosis of diabetic nephropathy.