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目的 探究肠道线虫感染低度流行区群体化疗优化方案。 方法 在江苏省高邮市肠道线虫感染低度流行区选择 1个实验村 (目标化疗村 )和 2个对照村 (1个全民化疗村和 1个空白对照村 ) ,对目标化疗和集体化疗的疗效进行比较研究。化疗药物均用甲苯达唑 ,成人总剂量 60 0mg ,1.5d分 3次服 ,每次 2 0 0mg ;2～ 12岁儿童总剂量 40 0mg ,1d分 2次服 ,每次 2 0 0mg。以Kato Katz厚涂片法和透明胶纸肛拭法检查虫卵 ,评价疗效。 结果 目标化疗后人群肠道线虫感染率 (2 .0 7% )较化疗前 (8.68% )下降显著 (χ2 =10 .77,P <0 .0 1) ,其下降率 (76.15 % )高于集体化疗的下降率(5 1.2 1% ) (u =5 .67,P <0 .0 1)。空白对照的感染率变化不明显 (χ2 =0 .43 ,P >0 .0 5 )。 结论 在肠道线虫感染低度流行区 ,目标化疗与集体化疗效果相似 ,且目标化疗更经济 ,值得推广。
Objective To explore the optimal chemotherapy regimen of group chemotherapy in the low endemic area of intestinal nematode infection. Methods One experimental village (target chemotherapy village) and two control villages (one universal chemotherapy village and one blank control village) were selected in the low prevalence area of gut nematode infection in Gaoyou, Jiangsu Province. The target chemotherapy and group chemotherapy Comparison of efficacy. Chemotherapy drugs were mebendazole, the total adult dose of 60 0mg, 1.5d points 3 times service, each 200mg; 2 to 12-year-old children a total dose of 40 0mg, 1d 2 sub-service, each 200mg. Kato Katz thick smear and translucent adhesive tape anal swab test eggs, evaluate the efficacy. Results The rate of intestinal nematode infection (2. 07%) in patients after chemotherapy was significantly lower than that before chemotherapy (χ2 = 10.77, P <0.01), and the rate of decline was 76.15% The rate of decrease of colorectal chemotherapy (5 1.2 1%) (u = 5.67, P <0.01). The infection rate of blank control did not change significantly (χ2 = 0.43, P> 0.05). Conclusion In the low endemic area of intestinal nematode infection, the target chemotherapy is similar to the group chemotherapy, and the target chemotherapy is more economical and worthy of promotion.