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硫嘌呤甲基转移酶（thiopurinemethyltransferase，TPMT）是一种特异性催化杂环类和芳香类化合物的巯基甲基化反应的细胞内酶，对临床常用的硫嘌呤类药物的代谢过程和疗效发挥起关键作用。硫嘌呤类药物，如６－巯基嘌呤（６－mercaptopurine，６－MP）、６－硫鸟嘌呤（６－thio
Thiopurine methyltransferase (TPMT) is an intracellular enzyme that specifically catalyzes the sulfhydryl methylation reaction of heterocyclic and aromatic compounds. It plays a role in the metabolic processes and therapeutic effects of commonly used thiopurines. Key role. Thiopurine drugs such as 6-mercaptopurine (6-MP), 6-thioguanine (6-thio)