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目的观察重组人γ－干扰素（IFN－γ）治疗大鼠肝纤维化疗效。右法用二甲基亚硝胺（DMN）腹腔注射诱导大鼠肝纤维化模型，染毒开始及染毒3周后分别用IFN－γ须防和治疗肝纤维化，并与正常对照组和染毒对照组相比较，观察各组血清透明质酸（HA）、肝组织羟脯氨酸（Hyp）、病理肝纤维化程度分期及α-平滑肌肌动蛋白（α－SMA）变化。结果IFN-γ预防和治疗组肝纤维化程度明显轻于染毒对照组，α－SMA阳性细胞表达较染毒对照组明显减少，肝Hyp、血清HA水平较染毒对照组亦有显著降低。IFN－γ台疗组和IFN-γ预防组之间各项指标无显著差异。结论IFN-γ对DMN所致大鼠肝纤维化有较好疗效。
Objective To observe the therapeutic effect of recombinant human interferon-γ (IFN-γ) on hepatic fibrosis in rats. The right method with dimethylnitrosamine (DMN) intraperitoneal injection of rat induced by hepatic fibrosis model, the beginning of exposure and 3 weeks after exposure were treated with IFN-γ to prevent and treat liver fibrosis, and with the normal control group and The levels of hyaluronic acid (HA), hydroxyproline (Hyp), histological grade of hepatic fibrosis and α-smooth muscle actin (α-SMA) in each group were compared. Results The degree of hepatic fibrosis in the group of prevention and treatment of IFN-γ was significantly lower than that of the control group. The expression of α-SMA positive cells in the group of prevention and treatment of IFN-γ was significantly lower than that in the control group. The levels of Hyp in serum and serum HA were significantly lower than those in the control group. There was no significant difference between the groups of IFN-γ and IFN-γ. Conclusion IFN-γ has a good effect on DMN-induced hepatic fibrosis in rats.