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21世纪流感的第一次大范围流行是由猪来源的甲型H1N1流感病毒引起,该病毒基因组由猪流感、人流感、禽流感基因混合而成[1]。长期以来甲型H1N1流感(甲流)患者出现神经系统并发症被认为并不常见[2-3]。流感病毒感染导致中枢神经系统病理改变被认为是间接和多因素的[4],对H1N1是否感染脑或脑脊液依然存在争议[5]。作为收治重症和危重症甲流病例的定点医院,既往深圳市宝安区妇幼保健院重症监护中心(PICU)收治的危重型H1N1流感以呼吸系统改变为主,表现为重症肺炎及ARDS,但2012
The first pandemic of influenza in the 21st century was caused by the swine-origin Influenza A (H1N1) virus, which is a mixture of swine flu, human influenza and bird flu genes [1]. Nervous system complications have been considered uncommon in patients with influenza A (H1N1) influenza for a long time [2-3]. Influenza virus infection leading to pathological changes in the central nervous system is considered indirect and multifactorial [4], whether H1N1 is infected with brain or cerebrospinal fluid is still controversial [5]. As a designated hospital for treating severe and critically ill cases of A-flow, the critically ill H1N1 influenza treated by PICU, the former intensive care center of Bao’an District of Shenzhen Municipality, is characterized mainly by severe respiratory diseases and ARDS, but 2012