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血内皮素(endothelins,ET)和内皮源性舒张因子——一氧化氮(Nitric oxide,NO),是调节和参与机体生理和病理过程的重要细胞因子,它们与肾脏及肾小球疾病关系已有报道,但意见不一。为了探讨两者与慢性肾病之间的关系,我们对36例慢性肾病患者的血ET和NO水平进行测定,以期为慢性肾病的防治提供理论依据。 1 材料与方法 1.1 研究对象 36例均为近年来住院的慢性肾小球肾炎患者,男性15例,女性21例,年龄18～62岁,平均32.6±12.8岁,同时选择同期年龄、性别相匹配的体检者20例作为对照组。 1.2 方法 1.2.1 患者分组 将患者根据病情不同阶段,分成肾功能正常组(A组,n=12,血肌酐(Scr)<178μmol/L),氮质血症组(B组,n=10,178μmol/L≤Scr≤445μmol/L),尿毒症组(C组,n=14,Scr>445μmol/L)。
Endothelins (ET) and endothelium-derived relaxation factor (NO) are important cytokines that regulate and participate in the physiological and pathological processes of the body. Their relationship with renal and glomerular diseases has been There are reports, but different opinions. In order to explore the relationship between the two and chronic kidney disease, we measured the levels of ET and NO in 36 patients with chronic kidney disease, in order to provide a theoretical basis for the prevention and treatment of chronic kidney disease. 1 Materials and Methods 1.1 The study of 36 cases were hospitalized in recent years, chronic glomerulonephritis patients, 15 males and 21 females, aged 18 to 62 years, mean 32.6 ± 12.8 years, while choosing the same age and gender match 20 cases of physical examination as a control group. 1.2 Methods 1.2.1 Patient Group According to the different stages of the disease, the patients were divided into normal renal function group (A group, n = 12, Scr <178μmol / L), azotemia group (B group, n = 10,178 μmol / L≤Scr≤445μmol / L), uremia group (C group, n = 14, Scr> 445μmol / L).