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一、诱导性肝增生和肿瘤形成的毒理学目前所知,约有百余种具有诱导作用的药物和环境化学物引起动物肝重增加。虽然,它们的化学性质和应用范围有极大的不同,但均具有脂溶性。这些外源性化合物亦称诱导剂,大多数是人工合成的,仅少数是天然存在的。附表说明,肝增生效应通常与肝细胞分解药物和其它亲脂性物质的酶含量显著增加相联系。苯巴比妥是化学诱导剂中最典型的代表;第二类为降脂药物如阿菲诺平和Cyproterone acetate(CPA),它们影响机体脂类代谢,其诱导酶为乙酰转移酶、过氧化氢酶等;第三类诱
I. Inducible Liver Hyperplasia and Tumor Nephrotoxicity It is known to date that there are about 100 kinds of drugs and environmental chemicals that induce the liver weight increase. Although their chemical properties and application range are greatly different, they are all liposoluble. These exogenous compounds, also known as inducers, are mostly synthetic and only a few are naturally occurring. The table shows that hepatic proliferative effects are often linked to a significant increase in the enzyme content of hepatocyte decomposing drugs and other lipophilic substances. Phenobarbital is the most typical chemical inducer; the second is a lipid-lowering drug such as adefovir dipivoxil and Cyproterone acetate (CPA), which affect the body lipid metabolism, the induced enzyme acetyltransferase, hydrogen peroxide Enzymes, etc .; the third category induced