服用洋地黄的住院病人,洋地黄中毒的发生率在8～20%之间。近来的前瞻性研究表明,内科入院病人中有15%接受某种洋地黄制剂。其中23%肯定地、6%可能发生过洋地黄中毒,而11%则为洋地黄用量不足。在所有的观察中,最高的中毒发生率是在老年组,洋地黄中毒的总死亡率为10%左右。为何会有如此高的中毒发生率?经典的解释是由于治疗和中毒浓度之间的安全范围较小,且常不易察觉药物的最佳作用浓度(尤其是当病人处于窦性节律时)。Withering建议,此后很多人也这样讲授,取得足量洋地黄化的正确方法是:给予洋地黄药物直至产生某些中毒症状,这样可以达到各病人所需 Inpatients taking digitalis, the incidence of digitalis poisoning in 8 to 20%. Recent prospective studies have shown that 15% of medical admissions patients receive some digitalis preparations. Of these, 23% certainly, 6% may have digitalis poisoning, while 11% digitalis is under-used. In all observations, the highest incidence of poisoning was in the elderly group, with a total mortality of digitalis poisoning of about 10%. Why is there such a high incidence of poisoning? The classic explanation is due to the small range of safety between treatment and toxic concentrations, and often not easy to detect the optimal concentration of the drug (especially when the patient is in sinus rhythm). Withering suggested that since then a lot of people have also taught that the right way to get a good amount of digitalis is to give digitalis drugs until they have some symptoms of poisoning that will meet the needs of each patient