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目的探讨恶性血液病合并侵袭性真菌感染患者的临床特点。方法回顾性分析2006年4月-2012年4月期间在柳州市人民医院住院治疗的恶性血液病合并侵袭性真菌感染患者65例临床资料。结果侵袭性真菌感染部位最主要在肺部(78.46%),真菌种类以白色念珠菌(33.33%)及热带念珠菌(23.81%)最多,抗真菌治疗有效率为63.08%;持续性低中性粒细胞血症5 d以上(χ2=19.701,P=0.000)、使用广谱抗生素7 d以上(χ2=16.749,P=0.001)、化疗过程使用糖皮质激素(χ2=17.340,P=0.000)是导致恶性血液病患者真菌感染的危险因素。结论对存在一定危险因素的恶性血液病患者应注意预防侵袭性真菌感染并及早予预防治疗。
Objective To investigate the clinical features of patients with hematologic malignancies complicated with invasive fungal infection. Methods The clinical data of 65 patients with malignant hemorrhagic disease complicated with invasive fungal infection hospitalized in Liuzhou People’s Hospital from April 2006 to April 2012 were retrospectively analyzed. Results Most of the sites of invasive fungal infection were in the lung (78.46%), most of which were Candida albicans (33.33%) and Candida tropicalis (23.81%), the effective rate of antifungal therapy was 63.08% Cytocytosis was more than 5 d (χ2 = 19.701, P = 0.000), with broad-spectrum antibiotics over 7 d (χ2 = 16.749, P = 0.001) and glucocorticoid (χ2 = 17.340, P = 0.000) Risk factors for fungal infections in patients with hematologic malignancies. Conclusion Patients with hematologic malignancies who have certain risk factors should pay attention to the prevention of invasive fungal infection and prevent and treat them as soon as possible.