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目的:观察活血化瘀利水方对急性软组织损伤大鼠肌肉组织中IL-1β(白细胞介素-1β)和PGE-2(前列腺素E-2)的影响,探讨其干预急性软组织损伤模型修复的可能机制。方法:将60只大鼠随机分为6组,即对照组、模型组、伤科跌打片组、活血化瘀利水方低、中、高剂量组,除对照组外,余5组通过打击法造成急性软组织损伤大鼠模型,连续给药7d后测定大鼠损伤肌肉组织中IL-1β和PGE-2含量。结果:活血化瘀利水方组与模型组比较有明显差异,且其抑制作用与药物剂量正相关,高剂量组抑制效果优于伤科跌打片组。结论:活血化瘀利水方对损伤局部炎症反应具有抑制作用,从而发挥对急性软组织损伤动物模型的治疗作用。
Objective: To observe the effects of “Huoxue Huayu Recipe” on IL-1β (IL-1β) and PGE-2 (prostaglandin E-2) in muscle tissue of rats with acute soft tissue injury and to explore its effects on the repair of acute soft tissue injury model Possible mechanism. Methods: 60 rats were randomly divided into 6 groups, namely, control group, model group, injury injury tablets, and blood circulation of low, medium and high dose group, in addition to the control group, the other 5 groups by blow Act induced acute soft tissue injury rat model, after continuous administration of 7d rat muscle tissue injury determination of IL-1β and PGE-2 content. Results: Compared with the model group, there was a significant difference between the traditional Chinese medicine group and the model group. The inhibitory effect was positively correlated with the dose of the drug. The inhibitory effect of the high-dose group was better than that of the injury-injured group. Conclusion: Huoxue Huayu Recipe has an inhibitory effect on the local inflammatory response to injury, so as to exert the therapeutic effect on animal model of acute soft tissue injury.