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目的探讨妊娠期高血压病女性维生素E口服对血脂指标水平的影响。方法选取范县中医院近期收治的妊娠期高血压病女性80例,其中40例给予维生素E(50 mg/d,2次/d)口服至分娩当天,设为C组,40例不给予任何干预,设为D组;选取同期正常妊娠女性80例,其中40例给予维生素E口服50 mg/d至分娩当天,设为B组,40例不给予任何干预,设为A组;比较四组女性三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)及高密度脂蛋白(HDL)水平。结果 B组女性血清TG、TC、LDL及HDL水平显著低于A组,差异有统计学意义(P<0.05);C组女性血清TG、TC、LDL及HDL水平显著高于A、B组,差异有统计学意义(P<0.05);D组女性血清TG和LDL水平显著高于A、B及C组,差异有统计学意义(P<0.05);D组女性血清TC和HDL水平显著高于A、B组,差异有统计学意义(P<0.05)。结论妊娠期高血压病女性维生素E口服可有效降低血清TG、TC、LDL水平,提高血清HDL水平,在改善血脂代谢异常方面作用确切。
Objective To investigate the effects of oral administration of vitamin E on the level of serum lipids in hypertensive patients with gestational hypertension. Methods Eighty women with hypertensive disorder complicating pregnancy were randomly selected from Fanxian Hospital of Traditional Chinese Medicine. Forty patients were given oral vitamin E (50 mg / d, twice daily) until the day of delivery, and were assigned to Group C. 40 Intervention, set to D group; Select the normal pregnancy women 80 cases, of which 40 cases given vitamin E orally 50 mg / d to the day of delivery, as the B group, 40 without any intervention, set A; compare the four groups Female triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL) and high density lipoprotein (HDL) levels. Results The serum levels of TG, TC, LDL and HDL in group B were significantly lower than those in group A (P <0.05). The levels of serum TG, TC, LDL and HDL in group C were significantly higher than those in groups A and B, (P <0.05). The levels of TG and LDL in serum of women in group D were significantly higher than those in groups A, B and C (P <0.05), and the levels of serum TC and HDL in group D were significantly higher In A, B group, the difference was statistically significant (P <0.05). Conclusion The oral administration of vitamin E in patients with hypertensive disorder during pregnancy can effectively reduce the levels of serum TG, TC and LDL, raise the level of serum HDL, and play an important role in the improvement of abnormal lipid metabolism.