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AIM: To investigate the effects of novel hydrophilic chemotherapeutic drugs on growth and apoptosis in human A549 lung, SKV03 0vary and MCF7 breast carcinoma cell lines. MATERIALS & METHODS: Three new drugs: CQMU-0522,CQMU-0517 and CQMU-0519 were utilized on A549 lung, SKV03 ovarian and MCF7 breast human cancer cell lines, where cell growth was assessed using cell culture kit-8 and flow cytometry analysis.Whereas apoptotic pathways for CQMU-0519 were unveiled by annexin-V FITC, apoptosis DNA ladder, caspases-3, 6, 8 and 9; meanwhile, regulation of Bcl-2 family members were analyzed by western blot analysis and ATP-Tumor Chemosensitivity Assay was used on a fresh lung adenocarcinoma tissue to highlight the concemed drug in chemotherapy. RESULTS: CQMU-0522, CQMU-0517 and CQMU-0519 all suppressed cell giowth in the three particular human cancer cell lines where cell cycle arrest was more evident in G2/M phase in the taxanes, while, CQMU-0522 caused cell cycle arrest in GO/G1 phase. Besides, in both human lung and ovarian cell lines treated with C.QMU-0519, apoptotic.levels were higher according to various tests perfonned and downregulation of Bcl-2 and Bcl-xL genes with increased expressions of Bad and Bax genes favored a more intrinsic pathway for apoptosis. Nevertheless, it was found that MCF7 cells though also manifesting lrigh levels of apoptosis preferred an extrinsic pathway instead of an intrinsic one. Since, lung adenocarcinoma cell line responded better to the CQMU-0519 in terms of apoptosis, we decided to check for its chemosensitivity which is important for the pathologist to guide the clinician directing chemotherapy; where response rate for growth inhibition was better between a certain range of test drug concentrations, Hence, showing that the new docetaxel, CQMU-0519 may have some prospective in the future in clinical trials. CONCLUSION: All the three new hydrophilic chemotherapeutic drugs analogues inhibit cell growth and CQMU-0519 enhances intrinsic apoptotic pathway in lung and ovarian carcinomas whereas chooses an extrinsic one in breast adenocarcinoma.