酿酒酵母Pdr5p对麦角甾醇代谢的影响及其机制研究

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真菌耐药性已成为真菌感染治疗上一个日益严峻的问题,由于麦角甾醇是真菌细胞膜上独特的脂类成分(在哺乳动物细胞膜中不含麦角甾醇而只含胆固醇),因此一直被作为设计抗真菌药物的最佳靶标之一真菌细胞中的脂类(包括麦角甾醇)合成后转运到细胞膜的途径有两种:小泡转运和非小泡转运。非小泡转运及其调控机制一直没有清楚阐述,近期的研究发现:ABC转运蛋白(ATP-binding cassette transporter),除了具有结合和外排底物分子(包括药物分子)的泵功能外,还与细胞中脂类的转运、代谢有着密切关
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